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Saturday, May 16, 2020 | History

5 edition of Cyclic nucleotide phosphodiesterases in health and disease found in the catalog.

Cyclic nucleotide phosphodiesterases in health and disease

Cyclic nucleotide phosphodiesterases in health and disease

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Published by CRC Press/Taylor & Francis in Boca Raton .
Written in English

    Subjects:
  • Cyclic nucleotide phosphodiesterases.,
  • Phosphoric Diester Hydrolases -- physiology.,
  • Nucleotides, Cyclic -- physiology.,
  • Phosphodiesterase Inhibitors -- therapeutic use.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by, Joseph A. Beavo, Sharron H. Francis, and Miles D. Houslay.
    ContributionsBeavo, Joe., Francis, Sharron H., Houslay, Miles D.
    Classifications
    LC ClassificationsQP609.C92 C93 2007
    The Physical Object
    Pagination713 p., [38] p. of plates :
    Number of Pages713
    ID Numbers
    Open LibraryOL17897554M
    ISBN 100849396689
    ISBN 109780849396687
    LC Control Number2006018995

    Chapter Title: Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Disease Book Title: Cyclic Nucleotide Phosphodiesterases in Health and Disease Author List: Yan C, Nagel DJ, Jeon KI Published By: CRC Press, Taylor and Francis Group in Boca Raton. VIEW ALL PUBLICATIONS. Cyclic Nucleotide Phosphodiesterases In Health And Disease EPub Format Associated Diseases Such As Asthma And Chronic Obstructive Pulmonary Disease Copd 2 More Than 30 New Chemical Book Title Cyclic Nucleotide. Phosphodiesterases In Health And Disease Author List Yan C Nagel Dj Jeon Ki Published By Crc Press Taylor And Francis Group In.

    Title: Cyclic Nucleotide Phosphodiesterases (PDE) and Peptide Motifs VOLUME: 16 ISSUE: 9 Author(s):Therese Keravis and Claire Lugnier Affiliation:CNRS UMR , Universite de Strasbourg, laboratoire de Biophotonique et Pharmacologie Faculte de Pharmacie, 74 route du Rhin, BP , Illkirch, France. Keywords:PDEs, regulatory domain, cAMP /cGMP signaling, peptide motif, Cited by: Chapter Title: Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Disease Book Title: Cyclic Nucleotide Phosphodiesterases in Health and Disease Author List: Yan C, Nagel DJ, Jeon KI Published .

    Cyclic nucleotide phosphodiesterases (PDEs) form an member superfamily comprising different isoforms that regulate the second messengers cyclic adenosine or guanosine 3′,5′-monophosphate (cAMP or cGMP). These PDE isoforms differ with respect to substrate selectivity and their localized control of cAMP and cGMP within nanodomains that target specific cellular pools and . Martin Biel, in Handbook of Cell Signaling (Second Edition), Introduction. Cyclic nucleotides exert their physiological effects by binding to four major classes of cellular receptors: cAMP- and cGMP-dependent protein kinases [1, 2], cyclic GMP-regulated phosphodiesterases [3], cAMP-binding guanine nucleotide exchange factors [4], and cyclic nucleotide-regulated cation channels.


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Cyclic nucleotide phosphodiesterases in health and disease Download PDF EPUB FB2

Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms.

It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic : Hardcover.

Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents.

Cyclic Nucleotide Phosphodiesterases in Health and Disease Pages pages Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the by: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field.

There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery helps scientists understand the concepts to develop more selective and potent inhibitors and modulators as treatments for neurological : Hardcover.

Phosphodiesterases in Health and Disease is a modern, comprehensive reference book on cyclic nucleotide phosophodiesterases (PDE) that will appeal to scientists in academia, the pharmaceutical industry, and related clinical disciplines. This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications.

A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. More specifically, he is interested in exploring the roles of phosphodiesterase (PDE)-mediated cyclic nucleotide (cAMP, cGMP) signaling in depression, anxiety, alcohol dependence, drug abuse, and cognition deficits associated with neurodegenerative disorders such as Alzheimer disease.

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation.

There are 11 different PDE families, with each family typically having several different isoforms and splice variants. These unique PDEs differ in their three-dimensional structure, kinetic properties, modes of regulation Cited by: Cyclic Nucleotide Phosphodiesterase Superfamily, J.

Beavo, M. Houslay, and S. Francis Phosphodiesterase Isoforms--An Annotated List, G. Bolger Section A Specific Phosphodiesterase Families--Regulation, Molecular and Biochemical Characteristics Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases, A. Bender PDE2 Structure and Functions, S.

Martinez. Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.

Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an. A guide to cyclic nucleotide phosophodiesterases (PDE). It describes the fundamental biochemical features of each of the known PDE families and the advances being made in developing selective inhibitors for these various enzymes.

Cyclic nucleotide phosphodiesterases (PDEs) have roles in numerous biological processes and their dysfunction has been associated with various diseases including those affecting the nervous system, Cited by: The term ‘cyclic nucleotide phosphodiesterase’ includes a variety of enzymes that catalyze the reaction: 3′,5′-cyclic nucleotides monophosphate + H 2 O → 5′ -nucleotide monophosphate.

These enzymes are specific for the cyclic diester and will not hydrolyze the 2′3′ -cyclic nucleotides that occur as intermediates of nucleic : Dolores J.

Takemoto. Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolytic destruction of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), to produce 5’-AMP and 5’-GMP, by: Download Phosphodiesterases In Health And Disease Pdf search pdf books full free download online Free eBook and manual for Business, Education, Finance.

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic Cited by: Modulation of the cyclic nucleotide phosphodiesterases (PDEs) superfamily is emerging as a possible therapeutic approach.

Indeed, through specific hydrolysis of cyclic AMP (cAMP) and/or cyclic GMP (cGMP), PDEs control short-term protein phosphorylation, long-term protein expression (Keravis & Lugnier, ; Maurice et al., ) and even Author: Claire Lugnier, Alain Meyer, Samy Talha, Bernard Geny.

A cyclic nucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate groups. Like other nucleotides, cyclic nucleotides are composed of three functional groups: a sugar, a nitrogenous base, and a single phosphate can be seen in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) images, the 'cyclic.

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes.

Because of the critical importance of cyclic nucleotide signaling in health and disease and the critical roles that PDEs play in regulating cyclic nucleotide signaling pathways and their biological effects, the mammalian PDE superfamily has been a major target for drug discovery (Bender and Beavo, ; Tsai and Kass, ; Francis et al, Cited by: Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signalling pathways and, consequently, myriad biological responses in health and by: Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signalling.